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Pulmonary and Critical Care Medicine

Online ISSN: 2398-3108

Yassine Amrani (Founding Editor in Chief)

University of Leicester

Pulmonary and Critical Care Medicine (PCCM) journal aims to publish peer-review material pertinent to specialists and general practitioners and addresses all aspects of respiratory medicine. PCCM will provide a platform in today's scientific and medical literature to serve as an international forum for the healthcare and scientific communities worldwide to translate novel "bench to bedside" research into clinical therapies as well as report upon prognostics, novel therapeutic strategies, and biomarker development. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants.

PCCM will feature original research, review papers, mini review, clinical studies, editorials, expert opinion and perspective papers, commentaries, and book reviews. Images providing advances or unusual contributions to the field are also published.

PCCM welcomes direct submissions from authors: Attach your word file with e- mail and send it to submissions@oatext.com alternatively to editor.pccm@oatext.com

Please, follow the Instructions for Authors. In the cover letter add the name and e-mail address of 5 proposed reviewers (we can choose them or not).

Copyright is retained by the authors and articles can be freely used and distributed by others. Articles are distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published by PCCM, is properly cited.

Dr Yassine Amrani


Dr Yassine Amrani is an internationally-recognized clinical scientist in the field of asthma pathogenesis. He obtained his PhD in Respiratory Medicine (Pharmacology) with the highest honor “summa com laude” from the University of Strasbourg, France.

Dr Amrani started his academic career at the University of Pennsylvania School of Medicine in Philadelphia, where he received his first appointment at the Department of Medicine in 2002. In 2007, he moved to the University Of Leicester (College of Medicine, Biological Sciences and Psychology) in the UK where he currently holds a tenured Readership (Associate Professor) in Respiratory Immunology. He is a member of the Institute for Lung Health and Principal Investigator at Leicester Respiratory Biomedical Research Unit at Glenfield Hospital.

Dr Amrani’s main research activities is around the use of translational “bench-to-bedside” approaches that could help in the development for more effective therapies for the treatment of lung diseases including severe asthma and COPD that are poorly controlled by current therapies. Dr Amrani has developed a strong interest in the immunomodulation of lung structural cells including bronchial smooth muscle and their sensitivity with anti-asthma drugs under inflammatory conditions.

One of Dr Amrani’s key contributions was to propose a novel concept that could explain the propensity of asthmatic airways to narrow excessively, a feature called bronchial hyperresponsiveness (BHR). The mechanisms of this exaggerated bronchoconstrictor response of the airways are still unknown. Dr Amrani studies showed that key pro-asthmatic cytokines such as TNF, IL-1 and IL-13 could directly act on bronchial smooth muscle and increase its sensitivity to bronchoconstrictor agonists via the modulation of calcium signaling. This concept could therefore explain the clinical benefit provided by anti-TNF (mab infliximab or fusion protein etanercept) or anti-IL-13 (lebrikizumab) therapies in severe asthmatics in recent clinical trials. This interesting area of research has since been confirmed and further explored by other independent groups around the world. The number of citations of the latest review written by Dr Amrani and colleagues in this particular field demonstrates the increasing interest and clinical importance of these findings (177 citations since 2008, Scopus).

Dr Amrani’s other major interests is aimed at better understanding why patients with severe asthma fail to properly respond to current therapies including glucocorticoids and bronchodilator drugs. Up to 10% asthmatics who poorly respond to corticosteroid therapy are responsible for more than 50% of the total health care costs and morbidity related to the disease. These patients have also the highest risk of dying from asthma and represent a huge management challenge for clinicians and represent a significant unmet need and novel therapies are urgently required. A better understanding of the mechanisms leading to corticosteroid insensitivity may lead to new therapeutic targets. In 2006, Dr Amrani’s group demonstrated that corticosteroid insensitivity could be induced in bronchial airway smooth muscle when exposed to inflammatory cytokines. This original observation supports the novel concept that under certain “asthmatic” conditions, airway structural cells could also participate in the pathogenesis of refractory asthma via the production of corticosteroid-resistant inflammatory mediators, thus contributing to disease severity. Recently, Dr Amrani received a 3-year grant from the Wellcome Trust to investigate how mast cells act as key players in asthma exacerbations by reducing patients’ response to beta2-agonists, the other main therapy for asthma.

Throughout his career, Dr Amrani received a total of $8 million worth of research and programme grants (as PI, co-PI and Co-investigator) from National Institute of Health (US), American Lung Association (US), Parker B. Francis Foundation (US). He is currently funded by the NIH (US), Medical Research Council (UK) and Wellcome Trust (UK) on grants. He has published over 90 peer-reviewed articles/reviews in top medical journals and wrote 9 book chapters in pulmonary medicine. His H-index is 35. He has delivered over 50 lectures in different Universities and acted as session chair at different meetings including American Thoracic Society (ATS) and American Academy of Allergy Asthma and Immunology (AAAAI). He served as a member of committee panels for funding bodies including NIH (USA), FAMRI (USA), and Health Research Board (Ireland) and ad hoc reviewer for the Wellcome Trust (UK), Medical Research Council (UK), British Lung Foundation (UK), Netherlands Asthma Foundation (Netherlands), Asthma UK (UK), Canadian Lung Association (Canada) among others and at least 25 prestigious top medical journals. He has trained more than 13 post-doctoral/clinical fellows and supervised the research project of 16 MSc students. He is currently a member of the European Respiratory Society (ERS).

Editorial Board


Lee M Akst

Department of Otolaryngology
Johns Hopkins Outpatient Center
USA

Hiroaki Kume

Professor of Respiratory Medicine and Allergology, and Community Health Care
Kinki University Faculty of Medicine
Japan

Jennifer Kathleen Quint

Department of Respiratory Epidemiology
National Heart and Lung Institute
Imperial College, UK


Sabina Janciauskiene

Department of Pulmonology
Hannover Medical School
Germany

Ching-Liang Hsieh

Director of the Graduate Institute of Integrated Medicine CMU
Center for Clinical Trials in Chinese Medicine
Taiwan

Imran H Iftikhar

Associate Professor of Medicine
Division of Pulmonary, Allergy, Critical Care & Sleep Medicine
The Ohio State University
USA


Enrico Heffler

Assistant Professor in Respiratory Medicine
University of Catania
Italy

Fumihiro Oshita

Chief of General Medicine
Kanagawa Prefectural Ashigarakami-Hospital
Japan

I Krivokuca

Head of the Department of Respiratory Medicine
MC Zuiderzee Hospital, Lelystad
The Netherlands


Muhammad Ali Javed

Assistant Professor of Medicine
Internal Medicine
Pulmonary, and Critical Care Medicine (American Board of Internal Medicine) Certifications
University of Missouri Kansas City
USA

Sukhen Samanta

Senior Resident (DM)
Department of Critical Care Medicine
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow
India

Dr. Gabriel V. Fontaine

Department of Pharmacy
Intermountain Medical Center
South Cottonwood Street
Murray, UT 84107
USA


Saeed Shoar

Research Fellow
Division of Colorectal Surgery
Houston Methodist Hospital
The University of Texas Medical School at Houston
Houston, TX
USA

In Press

Volume 2, Issue 3


Will be update soon.

Current Issue

Volume 2, Issue 2


Lung Involvement of an Infectious Disease Having Increasing Incidence

Lale Sertçelik Tulin Kuyucu Fatma Armagan Hazar Gulgun Cetintas Afsar Semra Bati Kutlu

Research Article-Pulmonary and Critical Care Medicine (PCCM)

June 21, 2017


Asthma-COPD Overlap Syndrome: A work in Progress

Julio E. González-Aguirre Roberto Mercado-Longoria

Mini review-Pulmonary and Critical Care Medicine (PCCM)

June 23, 2017


Atypical Traumatic of Pulmonary Artery after Rib Fractures

Massine EL Hammoumi El Hassane Kabiri

Case Report-Pulmonary and Critical Care Medicine (PCCM)

June 24, 2017


Non-neoplastic asbestos-related respiratory diseases: what relationship with other lung diseases?

Sartorelli P Bianchi F Paolucci P

Review Article-Pulmonary and Critical Care Medicine (PCCM)

June 28, 2017


Procalcitonin as a Biomarker for Infection and Sepsis: Yet Again

John L Moran Patricia J Solomon

Short Communication-Pulmonary and Critical Care Medicine (PCCM)

June 30, 2017


Targeted Temperature Management for Survivors of Sudden Cardiac Arrest

Alex M. Parker Matthew F. Gottbrecht Lawrence W. Gimple

Mini review -Pulmonary and Critical Care Medicine (PCCM)

July 27, 2017


Previous Issue

Volume 2, Issue 1


A Unique Case of Rapidly Progressive Diffuse Pulmonary Nodules

Madina Weiler Angelica Puopolo William Newmarch Brian Casserly

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 04, 2017


The Association between Elevated Troponin Levels and All Cause 30 Day Mortality in Critically Ill Patients Seen at an Academic Hospital – a prospective cohort study

Jospeh D, Ker J Rheeder P Ueckermann V

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March, 07, 2016


Treatment outcomes of new smear positive pulmonary tuberculosis patients under directly observed treatment in Anambra state, Nigeria

Nwachukwu Obiora Ndubuisi Onyeagba Reginald Azu Nwaugo Victor Oluoha Okafor Anthony

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 17, 2017


Exhaled breath analysis in lung transplant patients diagnosed with bronchiolitis obliterans syndrome

RM Hettiarachchi C Herbert AR Glanville PS Thomas

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March, 29, 2016


Promoting CPAP adherence in obstructive sleep apnea

Moussa Riachy

Editorial Article-Pulmonary and Critical Care Medicine (PCCM)

April 26, 2017


Archive


Volume 2

Lung Involvement of an Infectious Disease Having Increasing Incidence

Lale Sertçelik Tulin Kuyucu Fatma Armagan Hazar Gulgun Cetintas Afsar Semra Bati Kutlu

Research Article-Pulmonary and Critical Care Medicine (PCCM)

June 21, 2017


Asthma-COPD Overlap Syndrome: A work in Progress

Julio E. González-Aguirre Roberto Mercado-Longoria

Mini review-Pulmonary and Critical Care Medicine (PCCM)

June 23, 2017


Atypical Traumatic of Pulmonary Artery after Rib Fractures

Massine EL Hammoumi El Hassane Kabiri

Case Report-Pulmonary and Critical Care Medicine (PCCM)

June 24, 2017


Non-neoplastic asbestos-related respiratory diseases: what relationship with other lung diseases?

Sartorelli P Bianchi F Paolucci P

Review Article-Pulmonary and Critical Care Medicine (PCCM)

June 28, 2017


Procalcitonin as a Biomarker for Infection and Sepsis: Yet Again

John L Moran Patricia J Solomon

Short Communication-Pulmonary and Critical Care Medicine (PCCM)

June 30, 2017


Targeted Temperature Management for Survivors of Sudden Cardiac Arrest

Alex M. Parker Matthew F. Gottbrecht Lawrence W. Gimple

Mini review -Pulmonary and Critical Care Medicine (PCCM)

July 27, 2017


A Unique Case of Rapidly Progressive Diffuse Pulmonary Nodules

Madina Weiler Angelica Puopolo William Newmarch Brian Casserly

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 04, 2017


The Association between Elevated Troponin Levels and All Cause 30 Day Mortality in Critically Ill Patients Seen at an Academic Hospital – a prospective cohort study

Jospeh D, Ker J Rheeder P Ueckermann V

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March, 07, 2016


Treatment outcomes of new smear positive pulmonary tuberculosis patients under directly observed treatment in Anambra state, Nigeria

Nwachukwu Obiora Ndubuisi Onyeagba Reginald Azu Nwaugo Victor Oluoha Okafor Anthony

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 17, 2017


Exhaled breath analysis in lung transplant patients diagnosed with bronchiolitis obliterans syndrome

RM Hettiarachchi C Herbert AR Glanville PS Thomas

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March, 29, 2016


Promoting CPAP adherence in obstructive sleep apnea

Moussa Riachy

Editorial Article-Pulmonary and Critical Care Medicine (PCCM)

April 26, 2017


Volume 1

Granulomatosis with Polyangiitis (GPA)
Case Report Outlining the Importance of Urinalysis in Patients Presenting with Pulmonary Cavitary Lesions

Nicole Zagelbaum Zaineb Shamim Aamir Gilani Samer El Zarif Murali G Krishna Vivette D.D’Agati Sergio Obligado

Case Report-Pulmonary and Critical Care Medicine (PCCM)

November 24, 2016


Electroporation Ablation of Bronchial Smooth Muscle Cells: A Novel non-Thermal Asthma Therapy

Jason A. Tri Christopher V. DeSimone Craig Daniels Craig Daniels Roshini S. Asirvatham Susan B. Mikell Dorothy J. Ladewig Kelly Krajnick Samuel J. Asirvatham

Research Article-Pulmonary and Critical Care Medicine (PCCM)

November 06, 2016


Pulmonary Hemorrhage in Children

Anirban Mandal Puneet Kaur Sahi

Research Article-Pulmonary and Critical Care Medicine (PCCM)

December 16, 2016


Transbronchial Lung Cryobiopsy (TBLC) at a Tertiary Referral Hospital: A Two-Year Experience

Prachiti Dalvi Gabriella Kretz Stephen Clum Michael Markow David DiNuoscio Mark Rumbak Devanand Mangar Enrico Camporesi

Research Article-Pulmonary and Critical Care Medicine (PCCM)

December 28, 2016


S100A8, S100A9 and S100A12 Expression in Myeloid Cells from Whole Blood from Patients with Common Lung Diseases

Mann Ying Lim David Simar Sharron Chow Kenneth Hsu Craig R. Lewis Carolyn L. Geczy Paul S. Thomas

Research Article-Pulmonary and Critical Care Medicine (PCCM)

February 10, 2017


Diagnosis of Thymoma Metastasis via Endobronchial Ultrasound-guided Transbronchıal needle Aspiration

Ayperi Öztürk Taha Güllü Aydin Yilmaz Zafer Akta Funda Demirağ

Case Report-Pulmonary and Critical Care Medicine (PCCM)

December 31, 2016


Roscovitine Inhibits Endotoxin-Induced Lung Inflammation in Mice Lacking Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1 (PIN1)

Benjamin W NewellAmelia M SpauldingNam Y LeeDale G Hoyt

Research Article-Pulmonary and Critical Care Medicine (PCCM)

July 18, 2016


The Changing Epidemiology of Invasive Aspergillosis in the Non-Traditional Host: Risk Factors and Outcomes

Jose A Vazquez Maria Paula Tovar-Torresi Ameet Hingwe Faiqa Cheema Verna L Welch Kimbal D Ford

Research Article-Pulmonary and Critical Care Medicine (PCCM)

August 09, 2016


Deployment-related pulmonary symptoms and cardiopulmonary exercise testing in military personnel

Paul D. Hiles William H. Porr William N. Hannah Michael J. Morris

Research Article-Pulmonary and Critical Care Medicine (PCCM)

August 15, 2016


Anti-Synthetase Syndrome: Validity of ANA as a Screening Tool - The Oxford Interstitial Lung Disease Service Experience

Thomas Nicholson Andrew Woods Joel David Rachel Hoyles

Letter to Editor-Pulmonary and Critical Care Medicine (PCCM)

August 15, 2016


Role of surfactant protein D on in vivo alveolar macrophage phagocytosis of Cryptococcus neoformans by the regulation of p38 MAPK pathway activation

Osama Abdel-Razek Xiaoguang Liu Sara Javidiparsijani Guirong Wang

Research Article-Pulmonary and Critical Care Medicine (PCCM)

September 14, 2016


Pediatric Adverse Tracheal Intubation Associated Events Following Noninvasive Ventilation Failure

Christina Walsh Josep Panisello Joana Tala Akira Nishisaki Guillaume Emeriaud John S. Giuliano Jr

Research Article-Pulmonary and Critical Care Medicine (PCCM)

September 30, 2016


Pulmonary and Critical Care Medicine: Inviting Multidisciplinary Collaboration

Lee M Akst

Editorial-Pulmonary and Critical Care Medicine (PCCM)

April 15, 2016


MAG-DHA, Precursor of D-Series Resolvins, Induces Powerful Resolution of Various Components of Pulmonary Hypertension Induced By Monocrotaline in Rats

Roddy Hiram Caroline Morin Samuel Fortin Eric Rousseau

Research Article-Pulmonary and Critical Care Medicine (PCCM)

May 11, 2016


Percutaneous tracheostomy without bronchoscopy a safe procedure

Emídio Jorge Santos Lima

Research Article-Pulmonary and Critical Care Medicine (PCCM)

June 06, 2016


Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells

Sandra Grumelli German A Islan Guillermo R Castro

Review Article-Pulmonary and Critical Care Medicine (PCCM)

June 10, 2016


Absorption of FD&C Blue No. 1 from enteral feedings: A look back at a patient safety effort with modern relevance

James P Maloney Tracey A Brand

Research Article-Pulmonary and Critical Care Medicine (PCCM)

June 21, 2016


Effect of novel adenosine A3 receptor antagonist SSR161421 in allergic sheep models

Endre G Mikus Peter Aranyi Kinga Boer Geza Tímari Michel Finet Anne-Marie Galzin William M Abraham

Research Article-Pulmonary and Critical Care Medicine (PCCM)

June 25, 2016


Maternal use of montelukast in early pregnancy and infant congenital malformations

Bengt Källén

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 02, 2016


Hemodynamic effects of doxycycline combined with adrenomedullin during acute pulmonary embolism-induced pulmonary hypertension

Thalita L A Rocha Carlos A Dias-Junior

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 05,2016


The importance of applying diagnostic criteria from consensus 2011 to diagnose idiopathic pulmonary fibrosis (IPF) in a referral site

Jose Omar Barreto-Rodriguez Mayra Mejia Ivette Buendia-Roldan

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 08, 2016


In-hospital mortality, length of stay, and charges related to pulmonary fibrosis in the U.S. between 1993 and 2008

Daniel Fioret David Mannino Jesse Roman

Research Article-Pulmonary and Critical Care Medicine (PCCM)

March 18, 2016


Ganglioside GM1 for ischemic stroke: An update (2005-2015)

Li Li Tianlong Wang

Mini Review-Pulmonary and Critical Care Medicine (PCCM)

March 24, 2016


Inaugural editorial for pulmonary and critical care medicine

Yassine Amrani

Editorial-Pulmonary and Critical Care Medicine (PCCM)

March 24, 2016


Submit Manuscript


PCCM welcomes direct submissions from authors: Attach your word file with e- mail and send it to submissions@oatext.com alternatively to editor.pccm@oatext.com

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