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Effect of Ay Tsao fumigation disinfection in fence system on prevention of COVID-19

Jiang S

Henan University of Technology, Zhengzhou, 450001, China

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Liu Z

Henan University of Technology, Zhengzhou, 450001, China

DOI: 10.15761/FDCCR.1000146

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Abstract

A new type of coronavirus SARS-CoV-2 has erupted around the world, and China has now effectively controlled the epidemic in its territory, and providing strong support to the global fight against COVID-19. One of china's effective control measures is that the using of Ay Tsao fumigation disinfection to curb the spread of the virus. In response, we looked through government documents issued throughout China requesting the use of Ay Tsao fumigation disinfection, then we investigated the effectiveness of the elimination of all levels of medical institutions which use Ay Tsao fumigation disinfection, and the results showed these institutions achieved the desired results: so many medical units which used Ay Tsao fumigation disinfection has completely controlled the spread of the virus in their closed public space, and there was no infection in his inner space. Furthermore, based on the chemical structure of the synaptation of the volatile components of Ay Tsao and the SARS-CoV-2, we speculate the mechanism of the effective substances in Ay Tsao to against the SARS-CoV-2.

Key Words

Ay Tsao; fumigation disinfection; fence system; COVID-19; Government-issued documents

Introduction

According to Worldometers global real-time statistics, as of 07:30 Beijing time on April 10,2020, the number of confirmed cases of COVID-19 in the world has exceeded 1.6 million, reaching 1600185, of which 95559 have died. In the war between human and SARS-CoV-2, many countries need to recognize what has happened.

The Chinese Government promotes the use of Ay Tsao fumigation disinfection in public places

China's government decisively adopted closed isolation measures, and immediately to apply a combination of health management fence system [1] (Figure 1), which effectively curb the spread of the SARS-CoV-2 in China. China's efforts to fight the COVID-19 have earned time and experience for other countries. The palisade system has shown extremely high feasibility in preventing epidemic, hazardous, and infectious diseases over time, such as middle east respiratory syndrome (MERS) [2], severe acute respiratory syndrome (SARS) [3].

Figure 1. Combination of health management fence system

The system is mainly composed of 5 fences :1. Clean environment 2. Indoor air disinfection 3. Wear masks, wash hands, separate meals 4. Improve immunity diet 5. Physical exercise. The indoor air fumigation and disinfection in the fence system is required by Chinese government departments at all levels medical units. The fence principle of preventive measures: each fence is not as high as the highest infectious activity of the virus, but each fence can reduce the vitality of the virus to a certain extent (the percentage in the picture, obtained by statistics), and ultimately prevent the virus. So long as the virus does not erupt in the body, we can resist it through our own immunity; so long as the speed of transmission of the epidemic can be controlled, the epidemic will not crush medical system.

The second fence in the system is indoor disinfection, in which Ay Tsao fumigation (Figure 2) in a public closed space is an epidemic prevention measure with obvious characteristics of traditional Chinese medicine [4]. It is one of the most important methods of epidemic prevention in the documents issued by governments all over China. The smoke and volatiles produced by Ay Tsao can effectively block the transmission of the virus through aerosol (Figure 3). Therefore, the use of Ay Tsao fumigation disinfection in hospitals and wards can significantly prevent the occurrence of cross-infection [5]. The data shown that the average sterilization rate of indoor can reach 91% [6], which conforms to 96% and 100% of class II and III environmental hygiene standards, and has completely reached the hygienic standard of the total number of bacterial colonies in the ambient air of hospitals and wards. Moreover, Ay Tsao is cheap and easy to obtain in China. The use of Ay Tsao for fumigation is not only suitable for hospital air disinfection, but also for office, bus vehicles, home disinfection, which is very effective for a closed environment.

Figure 2. Ai fumigation disinfection case (A) Hotels in China are using emaciation (B) Clinics in China are using emaciation (C) Hospitals in China are using emaciation

Figure 3. The smoke from the burning Ay Tsao. (A) Ay Tsao Growing in China (B) The smoke from the burning Ay Tsao surrounds the virus particles

Figure 4. Molecular structure of spike glycoprotein at different angles

The Conception of the Anti-Virus Principle of Ay Tsao

According to the structure of the SARS-CoV-2 and the molecular characteristics of the "spike glycoprotein" (Figure 4), we speculated that the components of β-Caryophyllene (Figure 5) in the volatile material of Ay Tsao interacted with the virus particles, thus reducing the viral infection efficacy. β-Caryophyllene contains two double bonds, which can penetrate into the virus through the viral membrane and resonate with the two bonds in the ring structure of the atgc in the viral RNA, disrupting the environment of the RNA replication procedure, which may be a way to fumigate the virus. Wang analysied the clinical characteristics of 138 2019- nCoV inpatients in Wuhan, the results showed that 41.3% of the patients may have occurred through nosocomial infection [7]. And the Ay Tsao fumigation may be able to accelerate particle settling velocity through condensation and polymerization between small particles, thus blocking the SARS-CoV-2 propagation through aerosol (Figure 6).

Figure 5. Molecular structure of β-Caryophyllene

Figure 6. β-Caryophyllene interferes with virus spike glycoprotein

On the other hand, modern medical pharmacology has proved that Ay Tsao is an antibacterial and antiviral drug, which has the effect of inhibiting and killing germs, and also has the effect of preventing and treating respiratory diseases. There have been studies showing that the effective substances in Ay Tsao can stimulate the human immune system and guide human immune cells to phagocytosis of virus particles (Figure 7). existing in vitro experiments have shown that essential oils and other active components in Ay Tsao (Figure 8) have broad-spectrum antibacterial, antifungal, and viral inhibitory abilities. Modern studies have also proved that moxibustion therapy can catalyze, activate the body's immune system, improve the level of immune response, adjust the imbalance of norepinephrine (NE), serotonin (5-hydroxytryptamine), etc. In neurotransmitters, Ay Tsao can promote the stability of the environment within the collective so as to play a role in preventing and treating diseases [8].

Figure 7. Active substances in Ay Tsao activate the human immune system

Figure 8. Gas Chromatography of Essential Oil of Herba Ay Tsao

From the study of different viruses in vitro, it was found that the essential oil of Ay Tsao which extracted by steam distillation, had the activity of anti-acne-herpes zoster virus (varicella-zoster virus, VZV), and the higher the dose, the more lasting the inhibition effect [9]. The essential oil extracted from Ay Tsao growing in Henan Province has an inhibitory effect on hepatitis B virus (hepatitis B virus, HBV); its mechanism is to inhibit the replication of DNA, thus reducing the HBsAg and HbeAg expression of viral surface antigen [10]. The essential oil extracted from Ay Tsao growing in Hubei province can produce antiviral effect by inhibiting respiratory syncytial virus (respiratory syncytial virus,RSV) formation [11].

The epidemic prevention measures adopted in China by Ai fumigation disinfection benefit from China's abundant Ay Tsao resources, and various forms of Ay Tsao processing methods also make an important contribution to the large-scale use of Ay Tsao fumigation disinfection in China. where the graphene strip fumigant production line is shown in (Figure 9). The product has the advantages of high strength (up to metal material strength), waterproof, long-term fumigation (2h/cm), no environmental pollution (PM2.5) and so on.

Figure 9. Production of Ay Tsao products (A) Production line of Ay Tsao products (B) Graphene strip fumigant.

Results from the use of fumigation

Ay Tsao fumigation disinfection is included in the epidemic prevention program of governments around China (Figure 10), which will be used for a long time according to the current situation of the world epidemic. we counted the medical units that use emaciation to achieve 100% containment of virus infection (Table 1) and showed the effect of epidemic prevention and control in the area where the medical unit is located (Figure 11).

Figure 10. Notification of documents by Chinese government departments (A) Documents issued by Department of Wuhan Municipal Government (B) Documents issued by Department of Nanyang Municipal Government (C) Documents issued by Department of Nanjing Municipal Government

Figure 11. Effect map of epidemic prevention and control in the area using Ay Tsao fumigation disinfection (A) Regional map of the peak epidemic in China (B) Regional map of the controlled epidemic in China

Table 1. Medical units that use emaciation to completely eliminate the spread of the epidemic in their space

No

Place

Unite

1

Tongxu,Henan province

people's hospital of Tongxu

Zhengzhou, Henan province

ZHENGZHOU HOSPITAL OF TCM

Shangqiu,Henan province

SHANGQIU HOSPITAL OF TCM

Xinyang,Henan province

Xinyang Third People's Hospital

Nanyang,Henan province

NANYANG TCM HOSPITAL

2

Huanggang,Hubei province

HUANGGANG HOSPITAL OF TCM

Wuhan,Hubei province

HUBEI PROVINCIAL HOSPITAL OF TCM

Jiayu,Hubei province

JIAYU COUNTY HOSPITAL OF TCM

3

Hengshui,Hebei province

Hengshui Third People's Hospital

4

Guangzhou,Guangdong province

The First Affiliated Hospital of

Guangzhou University of Chinese Medicine

Gaozhou,Guangdong province

GAOZHOU CITY HOSPITAL OF TCM

5

Jinan,Shandong province

JINAN LICHENG HOSPITAL OF TCM

6

Nanchang,Jiangxi  province

JIANGXI PROVINCIAL HOSPITAL OF TCM

7

Lanzhou,Gansu province

GANSU HEPING HOSPITAL

Yuzhong,Gansu province

YUZHONG COUNTY HOSPITAL OF TCM

8

Fuquan,Guizhou province

FUZHOU HOSPITAL OF TCM

9

Changsha,Hunan province

HUNAN ACADEMY OF TCM  AFFILIATED HOSPITAL

Conclusion

The COVID-19 was first outbreak occurred in China, we did not get any warning, nor any experience from other countries to learn from, our country's public health infrastructure is not as good as developed countries. But China quickly and effectively contained the epidemic. According to the results of epidemic prevention and control in China, Ay Tsao fumigation disinfection can effectively prevent and control the spread of virus in public closed space, and can also purify the surface of objects and purify the environment of oral cavity and nasal cavity. This method is also applicable to developing countries and low-income people. Therefore, the use of Ay Tsao fumigation disinfection is an effective way to combat COVID-19.

Acknowledgement

“National Key R&D Program of China,2016YFD0400800”and applied for the Bill & Melinda Gates Foundation.

Reference

  1. Weishang Hu, Qiaofeng Wu (2020) Historical evolution and modern application of Chinese medicine fumigation and epidemic prevention. J Chinese herbal medicine 51: 895-901.
  2. Jie Hu, Jiahuai Duan (2013) Effect and Sterilization of Compound Ay Tsao Liquid. J Modern Integrated Chinese and Western Medicine Journal 22: 1261-1263.
  3. Xiaoping Chen, Peiyu Chen, Qiong Zhou (2005) Study on the disinfection dose of fumigated air in ward. J Journal of Traditional Chinese Medicine 01: 88-89.
  4. Wang DW, Hu B, Hu C (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. [Crossref]
  5. Yan Peng, Yingshuai Feng (2014) Effect of Moxibustion on Serum Immunology of Helicobacter pylori Gastritis Rats. Acupuncture and moxibustion in China 34: 783-790.
  6. Wu SB, Cao J, Wang TM (2015) Study on anti-fungal and anti-herpes zoster virus of volatile oil from Artemisia argyi. J Anhui Univ Chin Med 34: 70-71.
  7. Zhao ZH, Wang LY, Zheng LY (2015) The inhibition of volatile oil from Artemisia argyi to HBV. J Zhengzhou Univ 50: 301-304.
  8. Han Y, Dai C, Tang LY (2005) A preliminary study of virus-inhibiting effect of volatile oil from artemsia argyi. Amino Acids Biotic Resources 27: 14-16.

Editorial Information

Editor-in-Chief

Article Type

Research Article

Publication History

Received date: March 11, 2020
Accepted date: March 21, 2020
Published date: March 28, 2020

Copyright

©2020 Jiang S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Jiang S (2020) Effect of Ay Tsao fumigation disinfection in fence system on prevention of COVID-19 Frontiers Drug Chemistry Clinical Res, 2020 doi: 10.15761/FDCCR.1000146

Corresponding author

name

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Figure 1. Combination of health management fence system

Figure 2. Ai fumigation disinfection case (A) Hotels in China are using emaciation (B) Clinics in China are using emaciation (C) Hospitals in China are using emaciation

Figure 3. The smoke from the burning Ay Tsao. (A) Ay Tsao Growing in China (B) The smoke from the burning Ay Tsao surrounds the virus particles

Figure 4. Molecular structure of spike glycoprotein at different angles

Figure 5. Molecular structure of β-Caryophyllene

Figure 6. β-Caryophyllene interferes with virus spike glycoprotein

Figure 7. Active substances in Ay Tsao activate the human immune system

Figure 8. Gas Chromatography of Essential Oil of Herba Ay Tsao

Figure 9. Production of Ay Tsao products (A) Production line of Ay Tsao products (B) Graphene strip fumigant.

Figure 10. Notification of documents by Chinese government departments (A) Documents issued by Department of Wuhan Municipal Government (B) Documents issued by Department of Nanyang Municipal Government (C) Documents issued by Department of Nanjing Municipal Government

Figure 11. Effect map of epidemic prevention and control in the area using Ay Tsao fumigation disinfection (A) Regional map of the peak epidemic in China (B) Regional map of the controlled epidemic in China

Table 1. Medical units that use emaciation to completely eliminate the spread of the epidemic in their space

No

Place

Unite

1

Tongxu,Henan province

people's hospital of Tongxu

Zhengzhou, Henan province

ZHENGZHOU HOSPITAL OF TCM

Shangqiu,Henan province

SHANGQIU HOSPITAL OF TCM

Xinyang,Henan province

Xinyang Third People's Hospital

Nanyang,Henan province

NANYANG TCM HOSPITAL

2

Huanggang,Hubei province

HUANGGANG HOSPITAL OF TCM

Wuhan,Hubei province

HUBEI PROVINCIAL HOSPITAL OF TCM

Jiayu,Hubei province

JIAYU COUNTY HOSPITAL OF TCM

3

Hengshui,Hebei province

Hengshui Third People's Hospital

4

Guangzhou,Guangdong province

The First Affiliated Hospital of

Guangzhou University of Chinese Medicine

Gaozhou,Guangdong province

GAOZHOU CITY HOSPITAL OF TCM

5

Jinan,Shandong province

JINAN LICHENG HOSPITAL OF TCM

6

Nanchang,Jiangxi  province

JIANGXI PROVINCIAL HOSPITAL OF TCM

7

Lanzhou,Gansu province

GANSU HEPING HOSPITAL

Yuzhong,Gansu province

YUZHONG COUNTY HOSPITAL OF TCM

8

Fuquan,Guizhou province

FUZHOU HOSPITAL OF TCM

9

Changsha,Hunan province

HUNAN ACADEMY OF TCM  AFFILIATED HOSPITAL