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NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism

Alireza Heidari

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

American International Standards Institute, Irvine, CA 3800, USA

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Ricardo Gobato

Green Land Landscaping and Gardening, Seedling Growth Laboratory, 86130–000, Parana, Brazil

Lauro Figueroa Valverde

Laboratory of Pharmaco–Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Humberto Lanz Cárdenas S/N, Colonia Ex Hacienda Kalá, P. O. Box 24085, Campeche, México

DOI: 10.15761/DOMR.1000385

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Abstract

NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism has been applied in numerous scientific fields, from chemistry and biochemistry to arts and archaeology, as a powerful biospectroscopic technique which allows a spectral fingerprint capable of identifying the structure and function of gum cancer molecules, cells, tissues, or materials. In particular, its application to medical diagnostics has been of increasing interest in the past few decades.

Key words

NMR biospectroscopy, metabolomics, target biomarkers, DNA/RNA, diagnostic strategies, gum caner, tumor metabolism

Introduction

NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism has been reported for the detection of different types of ontologies, including cancer [1-10]. A large number of studies concerning the investigation of gum cancer with this particular NMR biospectroscopic technique have demonstrated its usefulness in understanding the disease progression at the molecular level. This review aims to compile the most significant achievements in this emerging research area.

Results and discussion

NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism provides a unique biochemical fingerprint capable of identifying and characterizing the structure of gum cancer molecules, cells, and tissues. In gum cancer, it is acknowledged as a promising biochemical tool due to its ability to detect premalignancy and early malignancy stages. This review summarizes the key research in the area and the evidence compiled is very encouraging for ongoing and further research. In addition to the diagnostic potential, promising results for HPV detection and monitoring treatment response suggest more than just a diagnosis prospective. A greater body of evidence is however necessary before NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism is fully validated for clinical use and larger comprehensive studies are required to fully establish the role of NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism in the molecular diagnostics of gum cancer (Figure 1).

Figure 1. Simulation of NMR–based metabolomics to target biomarkers such as DNA/RNA

Conclusion

The physical phenomenon of NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism has been extensively studied. It works on the principle that a small fraction (approximately 1 in 10 million) of the radiation scattered by certain molecules differs from that of the incident beam, and that the shift in wavelength depends upon the chemical structure of the molecules responsible for the scattering. NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism are acquired by irradiating a sample with a powerful laser source of usually visible or near–infrared monochromatic radiation and measuring the scattered radiation with a suitable spectrometer.

Acknowledgement

This study was supported by the Cancer Research Institute (CRI) Project of Scientific Instrument and Equipment Development, the National Natural Science Foundation of the United Sates, the International Joint BioSpectroscopy Core Research Laboratory Program supported by the California South University (CSU), and the Key project supported by the American International Standards Institute (AISI), Irvine, California, USA.

References

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  2. A. Heidari, C. Brown, “Study of Surface Morphological, Phytochemical and Structural Characteristics of Rhodium (III) Oxide (Rh2O3) Nanoparticles”, International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Volume 1, Issue 1, Pages 15–19, 2015.
  3. A. Heidari, “An Experimental Biospectroscopic Study on Seminal Plasma in Determination of Semen Quality for Evaluation of Male Infertility”, Int J Adv Technol 7: e007, 2016.
  4. A. Heidari, “Extraction and Preconcentration of N–Tolyl–Sulfonyl–Phosphoramid–Saeure–Dichlorid as an Anti–Cancer Drug from Plants: A Pharmacognosy Study”, J Pharmacogn Nat Prod 2: e103, 2016.
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  7. A. Heidari, “Study of Irradiations to Enhance the Induces the Dissociation of Hydrogen Bonds between Peptide Chains and Transition from Helix Structure to Random Coil Structure Using ATR–FTIR, Raman and 1HNMR Spectroscopies”, J Biomol Res Ther 5: e146, 2016.
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Editorial Information

Founding Editor-in-Chief

Shigeru Watanabe
Meikai University Japan

Editor-in-Chief

Vagner Rodrigues
Federal University of Minas Gerais

Article Type

Research Article

Publication history

Received: January 13, 2021
Accepted: February 04, 2021
Published: February 08, 2021

Copyright

©2021 Heidari A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Heidari A, Gobato R, Valverde LF (2021) NMR–based metabolomics approach to target biomarkers such as DNA/RNA for new frontiers of diagnostic strategies for prevention, prognosis, diagnosis and treatment of gum caner tumor metabolism. Dent Oral Maxillofac Res 7: DOI: 10.15761/DOMR.1000385

Corresponding author

Alireza Heidari

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604; American International Standards Institute, Irvine, CA 3800, USA

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Figure 1. Simulation of NMR–based metabolomics to target biomarkers such as DNA/RNA