Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road, NE, Atlanta, GA 30322, USA
E-mail :yamamasa1155@yahoo.co.jp
DOI: 10.15761/IMM.1000101
Figure 1. Chemical structure of Vitamin K.
Figure 2. Cellular mechanism by which menaquinone-7 (MK-7) stimulates osteoblastic bone formation and suppresses osteoclastic bone resorption. MK-7 suppresses NF-κB signaling pathways, which are activated by stimulation of TNF-α or RANKL, in osteoblasts and osteoclasts. In addition, MK-7 stimulates protein synthesis (including osteocalcin and other protein molecules) in osteoblastic cells, and it may regulate the gene expression of various proteins, which are related to cellular functions in osteblastic and osteoclastic cells.
