Vicente Notario graduated with a B.Sc. degree from the University of Salamanca, Spain, in 1974, and received his Ph.D. in Biology from the same institution in 1977. After completing post-doctoral training in the Department of Biochemistry of the University of Cambridge, England, and the U.S. National Cancer Institute, he joined the Department of Biochemistry at the Georgetown University Medical Center (G.U.M.C.) as a Research Assistant Professor, in 1986. Currently, Dr. Notario is Professor in the Departments of Radiation Medicine and of Biochemistry and Molecular & Cellular Biology. He is also Director of the Division of Radiation Research in the Department of Radiation Medicine. Dr. Notario has been Leader of the Radiation Biology & DNA Repair Program and the Molecular Targets & Therapeutic Resistance Program of the Lombardi Comprehensive Cancer Center, at the G.U.M.C. for over twenty years.
His laboratory has focused on understanding molecular and cellular mechanisms of cancer initiation and progression as well as those involved in the acquisition of resistance to anti-cancer therapy, with emphasis on pathways that may be exploited to improve the treatment of metastatic cancers and to sensitize human tumors to chemotherapeutic drugs and radiation therapies. In addition, the Notario laboratory studies molecular targets and pathways that may enhance the sensitivity to radiotherapy of Ewing’s sarcoma, a very aggressive type bone tumors that predominantly affect children and young adults. Related areas of research explore the anti-tumorigenic activity of the PEDF protein using various experimental systems for experimental carcinogenesis as well as the possible anti-cancer actions of human dietary components. Dr. Notario has authored over 140 publications and has been continuously funded by the U.S. National Cancer Institute since 1986.